Genome sequence of the model medicinal mushroom Ganoderma lucidum
نویسندگان
چکیده
Ganoderma lucidum is a widely used medicinal macrofungus in traditional Chinese medicine that creates a diverse set of bioactive compounds. Here we report its 43.3-Mb genome, encoding 16,113 predicted genes, obtained using next-generation sequencing and optical mapping approaches. The sequence analysis reveals an impressive array of genes encoding cytochrome P450s (CYPs), transporters and regulatory proteins that cooperate in secondary metabolism. The genome also encodes one of the richest sets of wood degradation enzymes among all of the sequenced basidiomycetes. In all, 24 physical CYP gene clusters are identified. Moreover, 78 CYP genes are coexpressed with lanosterol synthase, and 16 of these show high similarity to fungal CYPs that specifically hydroxylate testosterone, suggesting their possible roles in triterpenoid biosynthesis. The elucidation of the G. lucidum genome makes this organism a potential model system for the study of secondary metabolic pathways and their regulation in medicinal fungi.
منابع مشابه
Medicinal Mushroom Reishi (ganoderma Lucidum). Main Toxicity and Allergenicity Studies. Dosage, Posology and Side Effects
Medicinal mushroom Ganoderma lucidum has been subjected to intensive scientific research since the 80s, showing the multiplicity of its possible medicinal uses. Nowadays, Ganoderma is artificially cultivated in more than 10 countries, being China the first one in relation to its major production, followed by Korea, Taiwan, Japan, USA, Malasya, Vietnam, Indonesia and Sri Lanka. Also, its cultiva...
متن کاملMolecular identification of Ganoderma lucidum from Iran
Medicinal mushroom Ganoderma lucidum has been used in East Asia for centuries in order to prevent and treat a variety of diseases such as hepatitis, immunological disorders and cancers. In fact, this fungus contains a vast source of polysaccharides, proteins and secondary metabolites with anti-tumor and immuno-modulatory properties. Up to now, a variety of drug metabolites extracted from G. luc...
متن کاملA review of the effects of Reishi mushroom (Ganoderma lucidum) in preventing the aging process
Background: Reishi (Ganoderma lucidum) is a mushroom that has been used in Asian countries for thousands of years as a culinary-medicinal mushroom to treat a variety of diseases. Objective: To evalzuate the studies conducted on anti-aging effects of Reishi mushroom. Methods: Scopus, PubMed, Google Scholar, SID, and MagIran databases were used to search for articles published during 1989-2023...
متن کاملGeneration and Analysis of the Expressed Sequence Tags from the Mycelium of Ganoderma lucidum
Ganoderma lucidum (G. lucidum) is a medicinal mushroom renowned in East Asia for its potential biological effects. To enable a systematic exploration of the genes associated with the various phenotypes of the fungus, the genome consortium of G. lucidum has carried out an expressed sequence tag (EST) sequencing project. Using a Sanger sequencing based approach, 47,285 ESTs were obtained from in ...
متن کاملDeep Insight into the Ganoderma lucidum by Comprehensive Analysis of Its Transcriptome
BACKGROUND Ganoderma lucidum is a basidiomycete white rot fungus and is of medicinal importance in China, Japan and other countries in the Asiatic region. To date, much research has been performed in identifying the medicinal ingredients in Ganoderma lucidum. Despite its important therapeutic effects in disease, little is known about Ganoderma lucidum at the genomic level. In order to gain a mo...
متن کامل